Bernard B. Brodie

National Medal of Science

Biological Sciences

For pioneering new qualitative concepts which have revolutionized the development, the study, and the effective use of therapeutic agents in the treatment of human disease.

For pioneering new qualitative concepts which have revolutionized the development, the study, and the effective use of therapeutic agents in the treatment of human disease.

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Birth
May 20, 1910
Age Awarded
58
Country of Birth
England
Key Contributions
Interaction Of Drugs And Brain
Awarded by
Lyndon Baines Johnson
Education
McGill University
New York University
Areas of Impact
Theory & Foundations
Health & Medicine
Affiliations
National Institutes of Health
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When you cut your finger, the injured cells release chemicals called prostaglandins, sending a message through the nerves of your body to your brain. That message, known as “pain,” can be blocked using non-aspirin painkillers.

In the early 1900s, however, these drugs had unpleasant side effects, often causing a disorder called methemoglobinemia that generates red blood cell proteins incapable of carrying oxygen to body tissues.

In 1948, Bernard Brodie and his student, Julius Axelrod, linked the painkiller acetanilide to the condition and advocated for the use of acetaminophen instead. Several years later, the drug went on sale as “Tylenol.”

Throughout his career, the so-called father of modern pharmacology remained dedicated to investigating how the body – and chemicals like serotonin and norepinephrine – interact with medicine to treat conditions. Notably, Brodie investigated the way certain drugs are metabolized differently in different people, necessitating the need for dosage based on blood composition.

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